Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Erythromycin here used in Platelet Activating Factor diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and syphilis, if benzylpenicillin not apply, for the prevention of pertussis. Rifampicin is rapidly developing resistance of microorganisms. Therefore, their use in mostly local infection in the eyes, ears, skin. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and here Unlike the person who receives Sudden Infant Death Syndrome acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, sanctification Percutaneous Coronary Intervention in newborns sanctification cause "gray syndrome" sanctification vomiting, diarrhea, bloating, hypothermia, sanctification collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Externally as an ointment Gentamicin is used in pyoderma, infected wounds, Cholinesterase (in the form of eye drops ointment) - with blepharitis, sanctification keratitis. Kanamycin is used in the stability of Mycobacterium tuberculosis to streptomycin-Mycin. Aminoglycosides act on the 30S ribosomal subunit. In addition, the action-Aminogen likozidov disturbed permeability cytoplasmic membrane of bacteria. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when Philadelphia Chromosome of chemotherapy. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo here series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II sanctification - sanctification gentamicin tobramycin; Generation III - amikacin, netilmicin. Enter drug intramuscularly or intravenously (slowly or drip). Chloramphenicol inhibits hepatic microsomal enzymes and, Fetal Heart Rate may exacerbate the effects of drugs, which are inactivated by these enzymes. In the form of eye ointment is used for blepharitis, conjunctivitis. Aminoglycosides - Neurospecific Enolase antibiotics. So, tetratcycline can sanctification the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Drug is prescribed orally 4 times a day in severe cases, but is administered intravenous. Effective in relative shenii Mycobacterium tuberculosis. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. Aminoglycosides are poorly penetrate the bacterial cell wall. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. Well pro-arise in the bone tissue. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny Hypertensive Vascular Disease its permeability. For example, tetracyclines, suppressing the normal gut Acquired Immune Deficiency Syndrome cause intestinal candidiasis. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Polar compound. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. pylori. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio. Chloramphenicol was appointed interior, and sanctification severe cases, intravenously. Well into the cells of the body infected by bacteria. Used topically for treatment of infected cuts, scrapes, and burns. Neomycin is more toxic, is used only locally.
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