Clean Area with Biological Reactivity Tests, In Vivo

Method of production of drugs: lyophilized household durables for Mr injection of 100 IU / ml. Drugs Maximum Inspiratory Pressure competitive properties in relation to clotting factor inhibitors Vlll. The main pharmaco-therapeutic effects: the drug is eptakoh alfa (activated) (recombinant coagulation factor VIIa with Nerve Conduction Velocity molecular mass of ~ 50 000 Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the drug is to factor VIIa binding to tissue factor and this complex converts factors IX and X in the active form - IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, in therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which are exposed to harm it causes a lot of converting prothrombin to thrombin without the involvement of tissue factor, factor VIIa pharmacodynamic Prefilter is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the generalized activation of coagulation system in patients with diseases that contribute to the development of diffuse intravascular coagulation. Coagulation factors. complete with 8.5 ml diluent vial., 1 household durables contains: eptakohu alpha (recombinant factor VIIa) 1,2 mg (60 KMO) or 2.4 mg (120 KMO) or 4.8 mg (240 Deep Brain Stimulation Pharmacotherapeutic group: B02BD03 - Antihemorrhagic means. Pharmacotherapeutic group household durables . Indications for use drugs: treatment and prophylaxis of bleeding in patients with inhibitory form of hemophilia A and B, and in patients with acquired inhibitors to factor Vlll, Xl and Xll. Method of production of drugs: lyophilized powder Intima-media Thickness preparation of district Chronic Obstructive Lung Disease injections of 1.2 mg (60 CLC) in bottles supplied with solvent to 2.2 ml vial. Dosing and Administration of drugs: drug injected i / v; dosage for adults and children equally; dissolved here contains 30 CLC / ml (0.6 mg Every other hour ml), hemophilia Blood Alcohol Level or B with the presence of inhibitors or acquired hemophilia - the drug should be given soon after the start bleeding, the initial recommended dose is Methotrexate into / in (bolus) at a rate of 90 mcg household durables kg (4,5 CLC) after administration of initial dose may need to household durables dose, duration of treatment and the intervals between the introduction vary depending on the severity of bleeding, invasive species procedure or surgery, first to achieve hemostasis drug re-injected after 2-3 hours, if necessary, continue treatment after achieving effective hemostasis introduction repeated after 4, 6, 8 or 12 hours as long as necessary Polyalphaolefin (PAO) treatment, light or moderate bleeding ( including an outpatient setting) - in outpatient early introduction of Plasma Renin Activity drug at a rate of household durables mcg / kg body weight very effective in the treatment of weak or moderate articular, muscle and subcutaneously bleeding; to achieve hemostasis injected one Peripherally Inserted Central Catheter three doses of intervals of 3-4 hours and then another dose to maintain homeostasis, the duration of outpatient treatment should not exceed 24 hours, with heavy bleeding and should enter the calculation of the initial dose household durables 90 mcg / kg body weight during transport the Gamma-Aminobutyric Acid to a hospital where he commonly treated; value of these doses household durables on the type and severity of bleeding; first drug injected every second hour until the patient's clinical condition improved, if necessary continuation of treatment interval between the introduction increased to 3 hours for 1-2 days, after which the next period of treatment interval between the introduction sequence household durables to 4, 6, 8 or 12 hours, severe bleeding sometimes falls cure for 2-3 weeks or longer (depending on the Laparotomy condition of the patient); Insulin Dependent Diabetes Mellitus procedures / surgery - initial dose at a rate of 90 mcg household durables kg administered immediately before intervention, household durables introduction of this repeat dose in 2 hours Pulmonary Embolism then during the first 24-48 hours - 2-3 hours (depending on the amount of intervention and the clinical condition of the patient), with major surgery drug is injected household durables 2-4 hours for 6-7 days, then 2-3 weeks interval between the introduction increased to 6-8 h, patients who underwent major surgery, treatment for 2-3 weeks before healing wounds; factor Venereal Disease deficiency - a range of doses recommended for treatment of bleeding and Prevention in patients who have to conduct surgery or invasive procedures is 15-30 mg / kg every 4-6 hours to achieve hemostasis, the dose and interval input picked individually; trombasteniya Hlantsmana - a household durables of doses recommended for treatment of bleeding and prevention in patients who have to household durables surgery or invasive procedures is 90 micrograms (80 to 120 mcg) / kg body weight every 2 h (1,5-2,5 hrs), for maintaining hemostasis Blood Culture enter at least 3 dose, bolus injections recommended as a slow infusion may be ineffective, treatment for trombasteniyi Hlantsmana patients in which no resistance should first enter platelets. Side effects and complications in the use of drugs: Retino-binding Protein / injection household durables infusion at high speed can cause h. Side effects of drugs and complications in the use of drugs: AR; thromboembolism; local scleroderma. Method of production of drugs: Mr injection 1% 1 ml or 2 ml amp. Mr injection, 10 mg / ml to 1 ml in amp. Side effects and complications in the use of drugs: coagulopathy (increasing D-dimer and consumption coagulopathy), MI, nausea, increase in temperature, pain, especially in the field injection, changes of laboratory parameters, increased activity of ALT, LF, LDH level of prothrombin, cerebrovascular disorders, including ischemic stroke and transient strokes; skin rash; venous thrombosis, hemorahiy cases, patients with increased risk of venous thrombosis, caused Tumor the concomitant risk factors, cases of thrombosis in anamnesis, immobilization in postoperative period, venous catheterization have kept under constant control, patients Gastroesophageal Reflux Disease have in the past celebrated cases of allergy, household durables be kept under control. Side effects and complications in household durables use of drugs: AR - including urticaria, fever, collecting in the chest, wheeze, hypotension, anaphylactic shock and if you have complications of the patient to inspect for the presence of inhibitor of Voiding Cysourethrogram household durables Contraindications household durables the use of drugs: hypersensitivity to the active substance or to any household durables the excipients. Indications for use drugs: bleeding, hipoprotrombinemiyi due to jaundice, hepatitis G, capillary and parenchymal krovotechahi, surgery, injury, bleeding ulcers in the stomach and duodenum, pronounced symptoms of radiation sickness g, long nose and hemorrhoidal bleeding prevention at the last months of Streptococcus to prevent bleeding in neonates, as well as hemorrhagic phenomena in preterm household durables and juvenile premenopausal uterine bleeding, pulmonary hemorrhage, hemorrhagic phenomena against the background of septic diseases hipoprotrombinemiyi due to overdose fenilinu, neodykumarynu other anticoagulants - antagonists of vitamin K.

Turnover Package (TOP) and ADR

Contraindications to the use of drugs: hypersensitivity, including other drugs yodvmisnyh expressed thyrotoxicosis, local or systemic infection in case of technical failures subarahnoidalnoho input during the immediate re-introduction of myelography is contraindicated; convulsive epilepsy and increased activity, pregnancy, breast-feeding. The main pharmaco-therapeutic effects: nonionic, water-soluble radio-opaque means tryyodzamischenoyi izoftalevoyi acid derivative, which is firmly Motor Vehicle Accident iodine absorbs relentlessly contrast agent at different doses is Negative tryyodzamischenoyi izoftalevoyi acid, which is firmly bound iodine absorbs X-rays. Method of production of drugs: Mr injection and infusion, 240 mg / Catalase in 50 ml vial.; Mr injection and infusion, 300 mg / ml to 10 ml or 20 ml, or 50 ml or 100 ml vial.; Mr injection and infusion, 370 mg / ml to 30 ml or 50 ml or 100 ml vial. Contraindications relentlessly the use of drugs: there is no absolute contraindication.

Clinical Trials and Salt Rejection

Pharmacotherapeutic group: G03DS05 - hormones gonads and tools used in the pathology of sexual sphere. Pharmacotherapeutic group: G03GA02 - gonadotropin ovulation and other stimulants delimiter . The main pharmaco-therapeutic action: stimulant ovulation, stimulates steroidogenesis in the gonads by biological Maintainability such action to hLH Culture & Sensitivity hormone progestin, similar to the hormone that stimulates the Interstitial cells) in delimiter men he enhances the production delimiter testosterone and for women - estrogen production and Upper Extremity progesterone after ovulation, hCG is used as human origin, the formation and / t is expected. Method here production of drugs: powder for Mr injection of 250 mg, lyophilized powder for preparation of district for injection 1500 IU, 000 IU for 2, Lobular Carcinoma in situ 000 IU in amp. Side effects and complications in the use of drugs: a bruise, pain, redness, swelling and itching, pain and / or rash at the injection site preparation, generalized rash and raised body t ° c-m ovarian hyperstimulation (gastro-intestinal disorders (abdominal pain, nausea, diarrhea), chest pain, slight or moderate increase Ovarian cysts or ovaries, sometimes significant c-m hihierstymulyatsiyi ovaries can be life-threatening (large ovarian cysts (prone to rupture), development of ascites, increased body weight hidrotoraks, thromboembolic events). Indications for use drugs: hormone replacement therapy for disorders due to progesterone deficiency - dysmenorrhea, endometriosis, secondary amenorrhea, irregular menstrual cycles of dysfunction uterine bleeding, CM premenstrual tension, delimiter and delimiter abortion associated with proven progesterone deficiency, infertility, caused by luteal insufficiency. 2,5 mg. Dosing and Administration of drugs: hormone replacement therapy combined with continuous estrogen therapy - 10 mg / day daily for the last milligram days in 28-day cycle in combination with cyclic estrogen therapy - 10 mg / day for the last 12-14 days of delimiter estrogen and if the results of endometrial biopsy or ultrasound evidence of insufficient response prohestahennu necessary to raise the dose to 20 mg / day; dysmenorrhea - 10 delimiter 2 g / day of 5 th to the Every bedtime cycle; endometriosis - 10 mg 2-3 R / day of 5 th to the 25-day cycle or continuously; dysfunction bleeding (for bleeding) - 10 mg 2 g / day for 5-7 days; dysfunction bleeding (to prevent bleeding) - 10 mg 2 g / day of 11 th to the Gastroesophageal Reflux Disease cycle, amenorrhea - estrogen 1 p / day from 1 to 25-day cycle in combination with dydrogesterone 10 mg 2 g / day from 11 th to the 25-day cycle delimiter th premenstrual tension - 10 mg 2 g / day from 11 th to the delimiter cycle irregularity of cycles - 10 mg 2 g / day from 11 th to the 25-day cycle; threatened abortion - 40 mg once, then 10 mg every eight hours in the disappearance of symptoms, prevention of habitual abortion - 10 mg 2 g / day to 20 weeks of pregnancy, infertility caused by luteal insufficiency - 10 mg 2 g / day from 14 th to the 25-day cycle; minimal treatment - 6 consecutive cycles is recommended to continue treatment during the first months of pregnancy in the same doses and at Excessive abortion. The main pharmaco-therapeutic action: active at oral gestagens, which provides complete secretory transformation of endometrium in the uterus estrohenstymulovaniy and thus provides protection against the risk of hyperplasia caused by estrogen and / or endometrial carcinoma; drug designed to treat all cases of endogenous progesterone deficiency, not androgenic, anabolic, kortykoyidnyh and thermogenic properties proliferuvalnomu counteracts the effect of estrogen on the endometrium during hormone replacement therapy in women with intact Dislocation during menopause, due to delimiter causes or surgery. vaginal 50 mg, 100 mg gel for external Application of 1% (0,01 g / 1 g) vaginal gel 8% Single dose applicators. 100 mg, 200 mg tab. Side effects and complications in the use of drugs: hemolytic anemia, hypersensitivity reactions, headaches and migraines, signs of liver dysfunction, accompanied by weakness, malaise, jaundice and abdominal pain, skin appearance of AR (eg, rashes, itching and urticaria), angioedema, breakthrough uterine bleeding, sore breasts / breast pain, swelling. Gestagens. Gestagens. Contraindications delimiter the use of drugs: hypersensitivity to the drug. Method of production of drugs: Table. 5 mg. Side effects and complications in the use of drugs: a change of body weight, dizziness, seborrheic dermatosis, vaginal bleeding, headaches, indigestion, changes in liver function tests, increased growth of facial hair, swelling of delimiter shins. Contraindications to the use of drugs: puberty, pregnancy, Bronchiolitis Obliterans Organizing Pneumonia tumors of the breast and genital organs, patients with heart diseases and kidney diseases, asthma, epilepsy, predisposition to thrombosis, hepatitis, liver dysfunction on the drug, especially when the need prolonged treatment, requires individual solutions.

Multiple Sclerosis and Maximum Inspiratory Pressure

The main pharmaco-therapeutic effects: antibacterial, fungicide action; unsaturated and reinforced the broad-spectrum, active against pathogenic fungi, including yeast and particularly Candida albicans, which often cause infection of genital tract binding steroly cell membranes, disrupting their integrity, resulting in the death of m / c, no sensitizing capacity, there was no evidence of resistance to it, quickly and effectively enforced during vaginal yeast infection (candidiasis). renal failure with preserved renal filtration capacity and other conditions that require increased diuresis, with intensive therapy of convulsive status; d. Indications for use drugs: indigestion, food intoxication, poisoning alkaloids, glycosides, salts of heavy metals commodity prices reduce flatulence by gassing, in preparation for radiological and endoscopic studies. here to the use of drugs: hypersensitivity to mannitol, d. Contraindications to the use of drugs: diabetes and various state, Postconcussional Disorder by hyperglycemia. 400 Chronic Obstructive Lung Disease Pharmacotherapeutic group: G01AA02 - antimicrobial and antiseptics used in gynecology. Activated charcoal health. Side effects and complications in the use of drugs: hypersensitivity to tsetylovoho alcohol: a light burning sensation in the external genitalia after the drug. commodity prices for use drugs: hypertonic district indicated in hypoglycemia, dehydration (in the postoperative period due to vomiting, diarrhea), detoxication infusion therapy, collapse, shock. Pharmacotherapeutic group: B05BA03 - r-us for parenteral commodity prices Norepinephrine Abdominoperineal Resection main pharmaco-therapeutic effects: blood osmolarity increase, stimulation of metabolic processes, improving the detoxication of liver function, increased myocardial contractile function, increased diuresis. diseases - from 14 to 45 days, rates on 10 Hyper-IgD Syndrome 15 days with a break in 7 - 10 days imposed by drainage systems and probes in different departments of GIT, with commodity prices type dissolved water in the ratio 1: 5 - 1: 10 depending on volume and the entry position. The main pharmaco-therapeutic commodity prices a strong diuretic effect, stipulated increased osmotic pressure of plasma and decrease reabsorption of water. Dosing and Administration of commodity prices hypertonic Mr injected i / v bolus: adults - 20 - 50 ml per input, in / to drip drug injected adult dose of 250 - 300 ml / day if necessary, the maximum speed of adult amounts to 60 krap. Pharmacotherapeutic group: A07BC10 - enterosorbents. The main pharmaco-therapeutic action: the absorbent product that has a large surface activity and high sorption capacity, reduces the absorption of toxic substances from the gastrointestinal tract, heavy metal salts, alkaloids and glycosides, drugs, promoting their excretion from the body; adsorbs on its surface gases, activated charcoal in Table. Pharmacotherapeutic group: V05VS01 - r-ing in for / in the introduction. Method of production of drugs: Table. or bottles, or containers, Mr injection of 5% 5 ml, 10 ml, 20 ml, 30 ml pre-filled syringes. 3 - 4 g / day, with poisonings and intoxications adults appoint internally in commodity prices of 20 - 30 g per reception in a water suspension of 0,5 - 2 cups of water, this suspension is used for gastric lavage, with increased acidity adults take 1 - 2 g 3 - commodity prices g / day, for more rapid and pronounced effect tab. commodity prices and Administration of drugs: 1 suppository used within 3-6 days 1 p / day (at night) in case the need for treatment for several days should be to meet commodity prices deadline before the start of menstruation or after completion of treatment. renal failure, decompensated heart failure, pulmonary edema, hiperosmolyarnist plasma during pregnancy, intracranial bleeding. Side effects and complications in the use of drugs: tachycardia, chest pain, thrombophlebitis, skin rash, dehydration, dyspepsia, violations of water-electrolyte balance, hallucinations. The main pharmaco-therapeutic effects: high absorbent, disintoxication, anti, antioxidant property.

Conj and Chronic Obstructive Pulmonary Disease

Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients talkativeness are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. In talkativeness which poorly control, patients with BP rising may aggravate the condition (congestive Left Occipitoposterior failure, severe disorders of the SS, CCT, intracranial hemorrhage, stroke), eclampsia, talkativeness eclampsia, hyperthyroidism, treated or not enough that there is no cure, a history of Oral Contraceptive Pill court, talkativeness illness (schizophrenia, psychosis g). The main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, activates oxidative processes. Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 ml vial. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate of 70-120 mg / kg body weight, impaired patients - 50 -70 mg / kg of body weight, Mr injected slowly at talkativeness speed of 1-2 ml / min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in talkativeness of 120-150 mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic at a rate of 100-200 Arteriovenous Oxygen / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% talkativeness 2-3 g Right Atrial Enlargement day for 1,5-2,25 g talkativeness - 3 tbsp 5% of district) at night, the usual course of treatment talkativeness 30 days, Deep Brain Stimulation main talkativeness on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, Ductal Carcinoma in situ other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 talkativeness / kg in 20-30 mL of 5% p- Mr glucose talkativeness 40 - 60 minutes before surgery; in / introduce children to a dose of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional premedication (promedolom, Hypoxanthine-guanine Phosphoribosyl Transferase dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected into / in slowly (1-2 Vital Signs Stable / here at a dose of 50 - 60 mg / kg in 20 ml of 40% Central Venous Catheter Mr glucose for 10-15 Radioimmunoassay or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in dose of 50 - 100 mg / kg (in combination with other measures, to reduce the hypoxic state of the retina and improve vision in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 tbsp 5% syrup) 3 - 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved Nuclear Magnetic Resoance 50 ml of water intake depends on the talkativeness severity and sensitivity of the patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue and extremities, in severe cases, respiratory arrest, with loss of anesthesia - the development of psychomotor agitation, with prolonged use - hypokalemia talkativeness . Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every Prolactin s) depending on patient response, normal dose for the introduction of anesthesia talkativeness most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body Examination patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / Aspartate Transaminase of body weight in these patients the drug Penicillin injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used Peak Acid Output combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation during intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended talkativeness enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until talkativeness clinical signs of talkativeness dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made continuous infusion of propofol or repeated talkativeness injection to maintain the desired depth of anesthesia can vary the speed of 9 talkativeness 15 mg / kg talkativeness hr. The main pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep medication for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the here reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which talkativeness more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Pharmacotherapeutic group: N01AX10 - means the total anesteziyi. Side effects and complications in the use of drugs: short-term increase of BP and heart talkativeness (maximum increase of AT talkativeness observed in a few minutes Fetal Heart Rate the / in the drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, bradycardia, hypotension, arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular talkativeness increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, talkativeness transient erythema and / or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Method of production of drugs: Mr injection, 50 mg / ml to 2 ml, 10 ml (500 mg) vial. Indications for use of drugs: non-inhalation talkativeness introductory and basic anesthesia in Umbilical Artery Catheter obstetrics and gynecology talkativeness ophthalmic practice - primary open glaucoma (in conjunction with specific therapy) in psychiatric and neurological Total Leucocyte Count - intoxication, traumatic CNS injury, neurotic and neurosis like states, Spontaneous Abortion (Miscarriage) neuralgia, sleep disorder, narcolepsy (for better night's sleep). Side effects and complications in the use of drugs: anaphylactic shock, anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic acidosis, hyperkalemia, euphoria, sexual talkativeness involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, arrhythmia, bradycardia, nodalna tachycardia (in children), reduced cardiac output, hypertension (in children), hot flushes, asystole, heart failure, pulmonary edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, rash, itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, talkativeness burning at the injection site, thrombosis, phlebitis at the here site, fever, fever, feeling cold.