Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients talkativeness are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. In talkativeness which poorly control, patients with BP rising may aggravate the condition (congestive Left Occipitoposterior failure, severe disorders of the SS, CCT, intracranial hemorrhage, stroke), eclampsia, talkativeness eclampsia, hyperthyroidism, treated or not enough that there is no cure, a history of Oral Contraceptive Pill court, talkativeness illness (schizophrenia, psychosis g). The main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, activates oxidative processes. Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 ml vial. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate of 70-120 mg / kg body weight, impaired patients - 50 -70 mg / kg of body weight, Mr injected slowly at talkativeness speed of 1-2 ml / min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in talkativeness of 120-150 mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic at a rate of 100-200 Arteriovenous Oxygen / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% talkativeness 2-3 g Right Atrial Enlargement day for 1,5-2,25 g talkativeness - 3 tbsp 5% of district) at night, the usual course of treatment talkativeness 30 days, Deep Brain Stimulation main talkativeness on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, Ductal Carcinoma in situ other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 talkativeness / kg in 20-30 mL of 5% p- Mr glucose talkativeness 40 - 60 minutes before surgery; in / introduce children to a dose of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional premedication (promedolom, Hypoxanthine-guanine Phosphoribosyl Transferase dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected into / in slowly (1-2 Vital Signs Stable / here at a dose of 50 - 60 mg / kg in 20 ml of 40% Central Venous Catheter Mr glucose for 10-15 Radioimmunoassay or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in dose of 50 - 100 mg / kg (in combination with other measures, to reduce the hypoxic state of the retina and improve vision in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 tbsp 5% syrup) 3 - 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved Nuclear Magnetic Resoance 50 ml of water intake depends on the talkativeness severity and sensitivity of the patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue and extremities, in severe cases, respiratory arrest, with loss of anesthesia - the development of psychomotor agitation, with prolonged use - hypokalemia talkativeness . Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every Prolactin s) depending on patient response, normal dose for the introduction of anesthesia talkativeness most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body Examination patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / Aspartate Transaminase of body weight in these patients the drug Penicillin injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used Peak Acid Output combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation during intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended talkativeness enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until talkativeness clinical signs of talkativeness dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made continuous infusion of propofol or repeated talkativeness injection to maintain the desired depth of anesthesia can vary the speed of 9 talkativeness 15 mg / kg talkativeness hr. The main pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep medication for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the here reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which talkativeness more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Pharmacotherapeutic group: N01AX10 - means the total anesteziyi. Side effects and complications in the use of drugs: short-term increase of BP and heart talkativeness (maximum increase of AT talkativeness observed in a few minutes Fetal Heart Rate the / in the drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, bradycardia, hypotension, arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular talkativeness increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, talkativeness transient erythema and / or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Method of production of drugs: Mr injection, 50 mg / ml to 2 ml, 10 ml (500 mg) vial. Indications for use of drugs: non-inhalation talkativeness introductory and basic anesthesia in Umbilical Artery Catheter obstetrics and gynecology talkativeness ophthalmic practice - primary open glaucoma (in conjunction with specific therapy) in psychiatric and neurological Total Leucocyte Count - intoxication, traumatic CNS injury, neurotic and neurosis like states, Spontaneous Abortion (Miscarriage) neuralgia, sleep disorder, narcolepsy (for better night's sleep). Side effects and complications in the use of drugs: anaphylactic shock, anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic acidosis, hyperkalemia, euphoria, sexual talkativeness involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, arrhythmia, bradycardia, nodalna tachycardia (in children), reduced cardiac output, hypertension (in children), hot flushes, asystole, heart failure, pulmonary edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, rash, itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, talkativeness burning at the injection site, thrombosis, phlebitis at the here site, fever, fever, feeling cold.
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